Dysregulated Microglial Cell Activation and Proliferation Following Repeated Antigen Stimulation.

ABSTRACT: Upon reactivation of quiescent neurotropic viruses antigen (Ag)-specific brain resident-memory CD8+ T-cells (bT_RM) may respond to de novo-produced viral Ag through the rapid release of IFN-γ, which drives subsequent interferon-stimulated gene expression in surrounding microglia. Through this mechanism, a small number of adaptive bT_RM may amplify responses to viral reactivation leading to an organ-wide innate protective state. Over time, this brain-wide innate immune activation likely has cumulative neurotoxic and neurocognitive consequences. We have previously shown that HIV-1 p24 Ag-specific bT_RM persist within the murine brain using a heterologous prime-CNS boost strategy. In response to Ag restimulation, these bT_RM display rapid and rob

SUBMITTER: Prasad S 

PROVIDER: S-EPMC8383069 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature