Comparative Efficacy of a High-Dose vs Standard-Dose Hepatitis B Revaccination Schedule Among Patients With HIV: A Randomized Clinical Trial.

ABSTRACT:

Importance

Active immunization for hepatitis B virus (HBV) infection is recommended in patients living with HIV. Limited evidence is available about the most appropriate regimen of HBV vaccination among those who have not responded to an initial schedule.

Objective

To determine the efficacy of a high-dose schedule compared with a standard dose of HBV vaccination.

Design, setting, and participants

This double-masked, parallel-group, randomized controlled trial included patients living with HIV at a single outpatient HIV and hepatology clinic in Chile for whom previous HBV vaccination had failed. Patients with hepatitis B surface antibody (anti-HBs) titers less than 10 IU/L after an initial HBV vaccination regimen were included. Consecutive patients were recruited betwe

SUBMITTER: Vargas JI 

PROVIDER: S-EPMC8383137 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature