Genomic Copy Number Variants in CML Patients With the Philadelphia Chromosome (Ph+): An Update.

ABSTRACT:

Background

Submicroscopic segmental imbalances detected by array-comparative genomic hybridization (array-CGH) were discovered to be common in chronic myeloid leukemia (CML) patients with t(9;22) as the sole chromosomal anomaly. To confirm the findings of the previous study and expand the investigation, additional CML patients with t(9;22) as the sole chromosomal anomaly were recruited and copy number variants (CNVs) were searched for.

Methods

Karyotyping tests were performed on 106 CML patients during January 2010-September 2019 in our Genetics Laboratory. Eighty-four (79.2%) patients had the Philadelphia (Ph) chromosome as the sole chromosomal anomaly. Only 49(58.3%) of these 84 patients had sufficient marrow or leukemia blood materials to additionally be inc

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8383316 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature