Tumor microenvironment is not an 'innocent bystander' in the resistance to treatment of head and neck cancers (Review).

ABSTRACT: Head and neck cancers are still one of the most common types of cancer in the world. They rank in the leading sixth place in terms of incidence globally, and the incidence continues to rise. The mortality rates remain at high levels. Pathological subclassification places squamous cell carcinoma of the head and neck (HNSCC) in the first place concerning the histological forms of head and neck cancers; a tumor with extremely aggressive behavior and high mortality rates. The tumor microenvironment is a very complex ecosystem of cellular and non-cellular components, characterized by unique features, that contribute to the appearance of immunosuppression and diminished anticancer immunity, impacting patient prognosis and treatment outcome. Despite many important advances in therapy, resistance

SUBMITTER: Mazilu L 

PROVIDER: S-EPMC8383332 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature