Cardiac amyloidosis screening using a relative apical sparing pattern in patients with left ventricular hypertrophy.

ABSTRACT:

Background

Cardiac amyloidosis (CA) mimics left ventricular hypertrophy (LVH). It is treatable, but its prognosis is poor. A simple screening tool for CA would be valuable. CA is more precisely diagnosed with echocardiographic deformation parameters (e.g., relative apical sparing pattern [RASP]) than with conventional parameters. We aimed to 1) investigate incremental benefits of echocardiographic deformation parameters over established parameters for CA screening; 2) determine the resultant risk score for CA screening; and 3) externally validate the score in LVH patients.

Methods

We retrospectively studied 295 consecutive non-ischemic LVH patients who underwent detailed diagnostic tests. CA was diagnosed with biopsy or ^99mTc-PYP scintigraphy. The base model compr

SUBMITTER: Nakao Y 

PROVIDER: S-EPMC8383373 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature