Experimental infectious challenge in pigs leads to elevated fecal calprotectin levels following colitis, but not enteritis.

ABSTRACT:

Background

Fecal calprotectin is largely applied as a non-invasive intestinal inflammation biomarker in human medicine. Previous studies in pigs investigated the levels of fecal calprotectin in healthy animals only. Thus, there is a knowledge gap regarding its application during infectious diarrhea. This study investigated the usefulness of fecal calprotectin as a biomarker of intestinal inflammation in Brachyspira hyodysenteriae and Salmonella Typhimurium infected pigs.

Results

Fecal samples from pigs with colitis (n = 18) were collected from animals experimentally inoculated with B. hyodysenteriae (n = 8) or from sham-inoculated controls (n = 3). Fecal samples from pigs with enteritis (n = 14) were collected from animals inoculated with Salmonella enterica serovar Typhimur

SUBMITTER: Barbosa JA 

PROVIDER: S-EPMC8383374 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature