Circulating MicroRNAs predict glycemic improvement and response to a behavioral intervention.

ABSTRACT:

Background

MicroRNAs may be important regulators of risk for type 2 diabetes. The purpose of this longitudinal observational study was to assess whether circulating microRNAs predicted improvements in fasting blood glucose, a major risk factor for type 2 diabetes, over 12 months.

Methods

The study included participants (n = 82) from a previously completed trial that tested the effect of restorative yoga on individuals with prediabetes. Circulating microRNAs were measured using a flow cytometry miRNA assay. Linear models were used to determine the optimal sets of microRNA predictors overall and by intervention group.

Results

Subsets of microRNAs were significant predictors of final fasting blood glucose after 12-months (R² = 0.754, p < 0.001) and changes in

SUBMITTER: Flowers E 

PROVIDER: S-EPMC8383422 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature