Age-related alteration in characteristics, function, and transcription features of ADSCs.

ABSTRACT:

Background and objectives

Adipose tissue-derived stem cells (ADSCs) autologous transplantation has been a promising strategy for aging-related disorders. However, the relationship between ADSCs senescence and organismal aging has not been clearly established. Therefore, we aimed at evaluating senescence properties of ADSCs from different age donors and to verify the influence of organismal aging on the proliferation and function of ADSCs in vitro, providing the theoretical basis for the clinical application of autologous ADSCs transplantation.

Methods and results

The ADSCs were obtained from 1-month-old and 20-month-old mice. The cells characteristics, functions, gene expression levels, apoptosis proportion, cell cycle, SA-β-gal staining, and transcription features were eval

SUBMITTER: Li K 

PROVIDER: S-EPMC8383427 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature