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An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters.

ABSTRACT: The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and druggable targets, the majority of SLCs remains understudied. One major hurdle in research on SLCs is the lack of tools, such as cell-based assays to investigate their biological role and for drug discovery. Another challenge is the disperse and anecdotal information on assay strategies that are suitable for SLCs. This review provides a comprehensive overview of state-of-the-art cellular assay technologies for SLC research and discusses relevant SLC characteristics enabling the choice of an optimal assay technology. The Innovative Medicines Initiative consortium RESOLUTE intends to accelerate research on SLCs by providing the scientific community with high-quality reagents, assay technologies and data sets, and to ultimately unlock SLCs for drug discovery.

SUBMITTER: Dvorak V 

PROVIDER: S-EPMC8383457 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters.

Dvorak Vojtech V   Wiedmer Tabea T   Ingles-Prieto Alvaro A   Altermatt Patrick P   Batoulis Helena H   Bärenz Felix F   Bender Eckhard E   Digles Daniela D   Dürrenberger Franz F   Heitman Laura H LH   IJzerman Adriaan P AP   Kell Douglas B DB   Kickinger Stefanie S   Körzö Daniel D   Leippe Philipp P   Licher Thomas T   Manolova Vania V   Rizzetto Riccardo R   Sassone Francesca F   Scarabottolo Lia L   Schlessinger Avner A   Schneider Vanessa V   Sijben Hubert J HJ   Steck Anna-Lena AL   Sundström Hanna H   Tremolada Sara S   Wilhelm Maria M   Wright Muelas Marina M   Zindel Diana D   Steppan Claire M CM   Superti-Furga Giulio G  

Frontiers in pharmacology 20210810

The solute carrier (SLC) superfamily represents the biggest family of transporters with important roles in health and disease. Despite being attractive and druggable targets, the majority of SLCs remains understudied. One major hurdle in research on SLCs is the lack of tools, such as cell-based assays to investigate their biological role and for drug discovery. Another challenge is the disperse and anecdotal information on assay strategies that are suitable for SLCs. This review provides a compr  ...[more]

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