Cerebral cortex and blood transcriptome changes in mouse neonates prenatally exposed to air pollution particulate matter.

ABSTRACT:

Background

Prenatal exposure to air pollutants is associated with increased risk for neurodevelopmental and neurodegenerative disorders. However, few studies have identified transcriptional changes related to air pollutant exposure.

Methods

RNA sequencing was used to examine transcriptomic changes in blood and cerebral cortex of three male and three female mouse neonates prenatally exposed to traffic-related nano-sized particulate matter (nPM) compared to three male and three female mouse neonates prenatally exposed to control filter air.

Results

We identified 19 nPM-associated differentially expressed genes (nPM-DEGs) in blood and 124 nPM-DEGs in cerebral cortex. The cerebral cortex transcriptional responses to nPM suggested neuroinflammation involvement, including C

SUBMITTER: Haghani A 

PROVIDER: S-EPMC8383458 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature