Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches.

ABSTRACT: Juvenile idiopathic arthritis (JIA) is the most common paediatric rheumatological disorder and is classified by subtype according to International League of Associations for Rheumatology criteria. Depending on the number of joints affected, presence of extra-articular manifestations, systemic symptoms, serology and genetic factors, JIA is divided into oligoarticular, polyarticular, systemic, psoriatic, enthesitis-related and undifferentiated arthritis. This review provides an overview of advances in understanding of JIA pathogenesis focusing on aetiology, histopathology, immunological changes associated with disease activity, and best treatment options. Greater understanding of JIA as a collective of complex inflammatory diseases is discussed within the context of therapeutic interventions

SUBMITTER: Zaripova LN 

PROVIDER: S-EPMC8383464 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature