Differential impacts of particulate air pollution exposure on early and late stages of spermatogenesis.

ABSTRACT:

Background

Despite increasing evidence that particulate air pollution has adverse effects on human semen quality, few studies examine the impact of air pollution on clinically relevant thresholds used to diagnose male fertility problems. Furthermore, exposure is often assessed using average air pollution levels in a geographic area rather than individualized estimates. Finally, physiologically-informed exposure windows are inconsistent.

Objectives

We sought to test the hypothesis that airborne particulate exposures during early-phase spermatogenesis will have a differential impact on spermatogenic formation compared to late-phase exposures, using an individualized model of exposure to particulate matter ≤ 2.5 µm and ≤ 10 µm (PM_2.5 and PM₁₀, respectively

SUBMITTER: Henry TD 

PROVIDER: S-EPMC8383784 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature