Tubulin acetylation promotes penetrative capacity of cells undergoing radial intercalation.

ABSTRACT: Post-translational modification of tubulin provides differential functions to microtubule networks. Here, we address the role of tubulin acetylation on the penetrative capacity of cells undergoing radial intercalation, which is the process by which cells move apically, insert between outer cells, and join an epithelium. There are opposing forces that regulate intercalation, namely, the restrictive forces of the epithelial barrier versus the penetrative forces of the intercalating cell. Positively and negatively modulating tubulin acetylation in intercalating cells alters the developmental timing such that cells with more acetylation penetrate faster. We find that intercalating cells preferentially penetrate higher-order vertices rather than the more prevalent tricellular vertices. Differen

SUBMITTER: Collins C 

PROVIDER: S-EPMC8383821 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature