Genomic markers associated with successful treatment of hypertension with lisinopril: A pilot study.

ABSTRACT:

Objective

To identify single nucleotide variants (SNVs) associated with lisinopril effectiveness.

Materials and methods

This was an observational study using a candidate gene approach to examine SNVs associated with lisinopril effectiveness. Drug effectiveness was defined as 10% decrease in systolic blood pressure at 1 week follow-up. We used the Illumina GWAS MEGA chip to examine variants in the renin/angiotensin pathway that may be associated with drug effectiveness.

Results

61 subjects were enrolled, and 33 (54.1%) were responsive to lisinopril therapy. SNVs in AGT (p = 0.0141), REN (p = 0.0192), and ACE2 (p = 0.0002) were found to be associated with successful treatment on lisinopril. Conclusion and relevance: SNVs in the renin and angiotensin

SUBMITTER: Flaten HK 

PROVIDER: S-EPMC8383846 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature