Inferring Population Histories for Ancient Genomes Using Genome-Wide Genealogies.

ABSTRACT: Ancient genomes anchor genealogies in directly observed historical genetic variation and contextualize ancestral lineages with archaeological insights into their geography and cultural associations. However, the majority of ancient genomes are of lower coverage and cannot be directly built into genealogies. Here, we present a fast and scalable method, Colate, the first approach for inferring ancestral relationships through time between low-coverage genomes without requiring phasing or imputation. Our approach leverages sharing patterns of mutations dated using a genealogy to infer coalescence rates. For deeply sequenced ancient genomes, we additionally introduce an extension of the Relate algorithm for joint inference of genealogies incorporating such genomes. Application to 278 present-da

SUBMITTER: Speidel L 

PROVIDER: S-EPMC8383901 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature