Simulating PIP₂-Induced Gating Transitions in Kir6.2 Channels.

ABSTRACT: ATP-sensitive potassium (K_ATP) channels consist of an inwardly rectifying K⁺ channel (Kir6.2) pore, to which four ATP-sensitive sulfonylurea receptor (SUR) domains are attached, thereby coupling K⁺ permeation directly to the metabolic state of the cell. Dysfunction is linked to neonatal diabetes and other diseases. K⁺ flux through these channels is controlled by conformational changes in the helix bundle region, which acts as a physical barrier for K⁺ permeation. In addition, the G-loop, located in the cytoplasmic domain, and the selectivity filter might contribute to gating, as suggested by different disease-causing mutations. Gating of Kir channels is regulated by different ligands, like G_βγ, H⁺, Na⁺,

SUBMITTER: Brundl M 

PROVIDER: S-EPMC8384051 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature