Epigenetic programming underpins B-cell dysfunction in peanut and multi-food allergy.

ABSTRACT:

Objective

Rates of IgE-mediated food allergy (FA) have increased over the last few decades, and mounting evidence implicates disruption of epigenetic profiles in various immune cell types in FA development. Recent data implicate B-cell dysfunction in FA; however, few studies have examined epigenetic changes within these cells.

Methods

We assessed epigenetic and transcriptomic profiles in purified B cells from adolescents with FA, comparing single-food-allergic (peanut only), multi-food-allergic (peanut and ≥1 other food) and non-allergic (control) individuals. Adolescents represent a phenotype of persistent and severe FA indicative of a common immune deviation.

Results

We identified 144 differentially methylated probes (DMPs) and 116 differentially expressed genes (DE

SUBMITTER: Imran S 

PROVIDER: S-EPMC8384135 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature