Toward prediction of abscopal effect in radioimmunotherapy: Pre-clinical investigation.

ABSTRACT:

Purpose

Immunotherapy (IT) and radiotherapy (RT) can act synergistically, enhancing antitumor response beyond what either treatment can achieve separately. Anecdotal reports suggest that these results are in part due to the induction of an abscopal effect on non-irradiated lesions. Systematic data on incidence of the abscopal effect are scarce, while the existence and the identification of predictive signatures or this phenomenon are lacking. The purpose of this pre-clinical investigational work is to shed more light on the subject by identifying several imaging features and blood counts, which can be utilized to build a predictive binary logistic model.

Materials and methods

This proof-of-principle study was performed on Lewis Lung Carcinoma in a syngeneic, subcutaneous mur

SUBMITTER: Mihaylov IB 

PROVIDER: S-EPMC8384195 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature