Metabolomics provide new insights into mechanisms of Wolbachia-induced paternal defects in Drosophila melanogaster.

ABSTRACT: Wolbachia is a group of intracellular symbiotic bacteria that widely infect arthropods and nematodes. Wolbachia infection can regulate host reproduction with the most common phenotype in insects being cytoplasmic incompatibility (CI), which results in embryonic lethality when uninfected eggs fertilized with sperms from infected males. This suggests that CI-induced defects are mainly in paternal side. However, whether Wolbachia-induced metabolic changes play a role in the mechanism of paternal-linked defects in embryonic development is not known. In the current study, we first use untargeted metabolomics method with LC-MS to explore how Wolbachia infection influences the metabolite profiling of the insect hosts. The untargeted metabolomics revealed 414 potential differential metabolites bet

SUBMITTER: Zhang HB 

PROVIDER: S-EPMC8384202 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature