The Risk of Postkidney Transplant Outcomes by Induction Choice Differs by Recipient Age.

ABSTRACT:

Background

Among adult kidney transplant (KT) recipients, the risk of post-KT adverse outcomes differs by type of induction immunosuppression. Immune response to induction differs as recipients age; yet, choice of induction is barely tailored by age likely due to a lack of evidence of the risks and benefits.

Methods

Using Scientific Registry of Transplant Recipients data, we identified 39336 first-time KT recipients (2010-2016). We estimated the length of stay (LOS), acute rejection (AR), graft failure, and death by induction type using logistic and Cox regression weighted by propensity score to adjust for confounders. We tested whether these estimates differed by age (65+ versus 18-64 y) using a Wald test.

Results

Overall, rabbit antithymocyte globulin (rATG) was ass

SUBMITTER: Ahn JB 

PROVIDER: S-EPMC8384398 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature