Platelet P2Y ₁₂ Receptor Deletion or Pharmacological Inhibition does not Protect Mice from Sepsis or Septic Shock.

ABSTRACT: Introduction  Platelets are increasingly appreciated as key effectors during sepsis, raising the question of the usefulness of antiplatelet drugs to treat patients with sepsis. Objective  Evaluate the potential contribution of the platelet P2Y ₁₂ receptor in the pathogenesis of polymicrobial-induced sepsis and septic shock in mice. Methods  The effects of P2Y ₁₂ inhibition using clopidogrel treatment and of platelet-specific deletion of the P2Y ₁₂ receptor in mice were examined in two severity grades of cecal ligation and puncture (CLP) leading to mild sepsis or septic shock. Results  Twenty hours after induction of the high grade CLP, clopidogrel- and vehicle-treated mice displayed a similar 30% decrease in mean arterial blood p

SUBMITTER: Rabouel Y 

PROVIDER: S-EPMC8384481 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature