Integration of Multiple-Omics Data to Analyze the Population-Specific Differences for Coronary Artery Disease.

ABSTRACT: Significant differences may exist among different descents, but the current studies are mainly based on European populations. In the present study, we analyzed the population-specific differences of coronary artery disease (CAD) between European and East Asian descents. In stage 1, we identified CAD susceptibility genes by gene-based tests in European and East Asian populations. We identified two novel susceptibility genes for CAD, namely, CUX2 and OAS3. In stage 2, we carried out meta-analyses for the population-specific variants. rs599839 (PSRC1) represented a protective variant for CAD in East Asian populations (OR_ASN = 0.72. 95% CI: 0.63-0.81) but a risk factor in European populations (OR_EUR = 1.13, 95% CI: 0.93-1.36). In stage 3, we enriched

SUBMITTER: Hu Y 

PROVIDER: S-EPMC8384508 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature