Immunomodulatory Effects of Canine Adipose Tissue Mesenchymal Stem Cell-Derived Extracellular Vesicles on Stimulated CD4⁺ T Cells Isolated from Peripheral Blood Mononuclear Cells.

ABSTRACT: Adipose tissue-derived mesenchymal stem cells (ADSCs) have anti-inflammatory and immunomodulatory characteristics. Many studies have suggested that the immunomodulation of ADSCs is largely mediated by secreted paracrine factors. Various factors are secreted from ADSCs, among which extracellular vesicles are considered to play a major role in the communication between ADSCs and target cells. Several studies have reported the function of canine ADSC-derived extracellular vesicles (cADSC-EVs), but few studies have reported the immunomodulatory effects of cADSC-EVs on immune cells. The purpose of this study was to investigate the effects of cADSC-EVs on in vitro-stimulated CD4⁺ T cells isolated from peripheral blood mononuclear cells (PBMCs). cADSC-EVs were isolated from cADS

SUBMITTER: Teshima T 

PROVIDER: S-EPMC8384509 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature