Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization.

ABSTRACT: Prurigo nodularis (PN) is an understudied, chronic inflammatory skin disease that disproportionately affects African Americans and presents with intensely pruritic nodules of unknown etiology. To better characterize the immune dysregulation in PN, PBMCs and skin biopsies were obtained from patients with PN and healthy subjects (majority African American) matched by age, race, and sex. Flow cytometric analysis of functional T-cell response comparing patients with PN with healthy subjects identified increased γδT cells (CD3⁺CD4^-CD8^-γδTCR⁺) and Vδ2⁺ γδT enrichment. Activated T cells demonstrated uniquely increased IL-22 cytokine expression in patients with PN compared with healthy controls. CD4+ and CD8+ T cells were identified as the sou

SUBMITTER: Belzberg M 

PROVIDER: S-EPMC8384659 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature