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New Frontiers in Psoriatic Disease Research, Part I: Genetics, Environmental Triggers, Immunology, Pathophysiology, and Precision Medicine.


ABSTRACT: Psoriasis is a chronic inflammatory condition characterized by systemic immune dysregulation. Over the past several years, advances in genetics, microbiology, immunology, and mouse models have revealed the complex interplay between the heritable and microenvironmental factors that drive the development of psoriatic inflammation. In the first of this two-part review series, the authors will discuss the newest insights into the pathogenesis of psoriatic disease and highlight how the evolution of these scientific fields has paved the way for a more personalized approach to psoriatic disease treatment.

SUBMITTER: Yan D 

PROVIDER: S-EPMC8384663 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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New Frontiers in Psoriatic Disease Research, Part I: Genetics, Environmental Triggers, Immunology, Pathophysiology, and Precision Medicine.

Yan Di D   Gudjonsson Johann E JE   Le Stephanie S   Maverakis Emanual E   Plazyo Olesya O   Ritchlin Christopher C   Scher Jose U JU   Singh Roopesh R   Ward Nicole L NL   Bell Stacie S   Liao Wilson W  

The Journal of investigative dermatology 20210722 9


Psoriasis is a chronic inflammatory condition characterized by systemic immune dysregulation. Over the past several years, advances in genetics, microbiology, immunology, and mouse models have revealed the complex interplay between the heritable and microenvironmental factors that drive the development of psoriatic inflammation. In the first of this two-part review series, the authors will discuss the newest insights into the pathogenesis of psoriatic disease and highlight how the evolution of t  ...[more]

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