Predictive Performance of a Polygenic Risk Score for Incident Ischemic Stroke in a Healthy Older Population.

ABSTRACT:

Background and purpose

Polygenic risk scores (PRSs) can be used to predict ischemic stroke (IS). However, further validation of PRS performance is required in independent populations, particularly older adults in whom the majority of strokes occur.

Methods

We predicted risk of incident IS events in a population of 12 792 healthy older individuals enrolled in the ASPREE trial (Aspirin in Reducing Events in the Elderly). The PRS was calculated using 3.6 million genetic variants. Participants had no previous history of cardiovascular events, dementia, or persistent physical disability at enrollment. The primary outcome was IS over 5 years, with stroke subtypes as secondary outcomes. A multivariable model including conventional risk factors was applied and reevaluated after addi

SUBMITTER: Neumann JT 

PROVIDER: S-EPMC8384668 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature