Dataset Information

Decreased secondary faecal bile acids in children with ulcerative colitis and Clostridioides difficile infection.

ABSTRACT:

Background

Patients with ulcerative colitis (UC) have an increased risk of Clostridioides difficile infection (CDI). There is a well-documented relationship between bile acids and CDI.

Aims

To evaluate faecal bile acid profiles and gut microbial changes associated with CDI in children with UC.

Methods

This study was conducted at Children's Hospital Los Angeles. Faecal bile acids and gut microbial genes related to bile acid metabolism were measured in 29 healthy children, 23 children with mild to moderate UC without prior CDI (UC group), 16 children with mild to moderate UC with prior CDI (UC+CDI group) and 10 children without UC with prior CDI (CDI group).