Decreased risk of non-infectious anterior uveitis with statin therapy in a large healthcare claims database.

ABSTRACT:

Purpose

The purpose of this study is to determine if statin therapy decreases the incidence of non-infectious uveitis (NIU) using a retrospective cohort study.

Methods

Patients enrolled in a national insurance plan who initiated statin (n = 711,734, statin cohort) or other lipid-lowering therapy (n = 148,044, non-statin cohort) were observed for NIU development. Incident NIU in the primary analysis was defined as a new diagnosis code for NIU followed by a second instance of a NIU code within 120 days. For the secondary outcome definition, a corticosteroid prescription or code for an ocular corticosteroid injection within 120 days of the NIU diagnosis code was used instead of the second NIU diagnosis code. Estimation of NIU incidence used multivariable Cox proportional hazard

SUBMITTER: Sobrin L 

PROVIDER: S-EPMC8384676 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature