Top Priorities for Cerebroprotective Studies-A Paradigm Shift: Report From STAIR XI.

ABSTRACT: Despite years of basic research and pioneering clinical work, ischemic stroke remains a major public health concern. Prior STAIR (Stroke Treatment Academic Industry Roundtable) conferences identified both failures of clinical trial design and failures in preclinical assessment in developing putative ischemic stroke treatments. At STAIR XI, participants in workshop no. 1 Top Priorities for Neuroprotection sought to redefine the neuroprotection paradigm and given the paucity of evidence underlying preclinical assessment, offer consensus-based recommendations. STAIR proposes the term brain cytoprotection or cerebroprotection to replace the term neuroprotection when the intention of an investigation is to demonstrate that a new, candidate treatment benefits the entire brain. Although "time is

SUBMITTER: Lyden P 

PROVIDER: S-EPMC8384700 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature