Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer.

ABSTRACT:

Background

Leukocytes, such as T cells and macrophages, play an important role in tumorigenesis. CC chemokine ligand (CCL) 4, which is produced by lymphocytes and macrophages, has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.

Aim

To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer (CRC) and evaluate their prognostic significance.

Methods

Luminex technology was used to determine CCL4 Levels in CRC tissue (n = 98), compared with paired normal tissue, and in plasma from patients with CRC (n = 103), compared with healthy controls (n = 97). Included patients had undergone surgical resection for primary colorectal adenocarci

SUBMITTER: Shamoun L 

PROVIDER: S-EPMC8384737 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature