Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients.
Ontology highlight
ABSTRACT: Background
Human leukocyte antigen (HLA) plays an important role in immune responses to infections, especially in the development of acquired immunity. Given the high degree of polymorphisms that HLA molecules present, some will be more or less effective in controlling SARS-CoV-2 infection. We wanted to analyze whether certain polymorphisms may be involved in the protection or susceptibility to COVID-19.Methods
We studied the polymorphisms in HLA class I (HLA-A, -B and -C) and II (HLA-DRB1 and HLA-DQB1) molecules in 450 patients who required hospitalization for COVID-19, creating one of the largest HLA-typed patient cohort to date.Results
Our results show that there is no relationship between HLA polymorphisms or haplotypes and susceptibility or protection to COVID-19.Conclusion
Our results may contribute to resolve the contradictory data on the role of HLA polymorphisms in COVID-19 infection.
SUBMITTER: Gutierrez-Bautista JF
PROVIDER: S-EPMC8384756 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Publications
Study of HLA-A, -B, -C, -DRB1 and -DQB1 polymorphisms in COVID-19 patients.
Gutiérrez-Bautista Juan Francisco JF Rodriguez-Nicolas Antonio A Rosales-Castillo Antonio A López-Ruz Miguel Ángel MÁ Martín-Casares Antonia María AM Fernández-Rubiales Alonso A Anderson Per P Garrido Federico F Ruiz-Cabello Francisco F López-Nevot Miguel Ángel MÁ
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20210825 3
<h4>Background</h4>Human leukocyte antigen (HLA) plays an important role in immune responses to infections, especially in the development of acquired immunity. Given the high degree of polymorphisms that HLA molecules present, some will be more or less effective in controlling SARS-CoV-2 infection. We wanted to analyze whether certain polymorphisms may be involved in the protection or susceptibility to COVID-19.<h4>Methods</h4>We studied the polymorphisms in HLA class I (HLA-A, -B and -C) and II ...[more]
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