Chlorpyrifos and Δ⁹ Tetrahydrocannabinol exposure and effects on parameters associated with the endocannabinoid system and risk factors for obesity.

ABSTRACT: Marilyn Silva. Retired from a career in toxicology and risk assessment. Increased childhood and adult obesity are associated with chlorpyrifos (CPF), an organophosphate pesticide. Cannabis (Δ⁹Tetrahydrocannabinol: Δ⁹THC) use has increased globally with legalization. CPF applications on cannabis crops lacks federally regulated tolerances and may pose health risks through exposure during development and in adulthood. Both CPF and Δ⁹THC affect the endocannabinoid system (eCBS), a regulator of appetite, energy balance, and gut microbiota, which, if disrupted, increases risk for obesity and related diseases. CPF inhibits eCB metabolism and Δ⁹THC is a partial agonist/antagonist at the cannabinoid receptor (CB1R). Effects of each on obesogenic parameter

SUBMITTER: Silva MH 

PROVIDER: S-EPMC8384771 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature