Behavioral and psychological impact of genome sequencing: a pilot randomized trial of primary care and cardiology patients.

ABSTRACT: Many expect genome sequencing (GS) to become routine in patient care and preventive medicine, but uncertainties remain about its ability to motivate participants to improve health behaviors and the psychological impact of disclosing results. In a pilot trial with exploratory analyses, we randomized 100 apparently healthy, primary-care participants and 100 cardiology participants to receive a review of their family histories of disease, either alone or in addition to GS analyses. GS results included polygenic risk information for eight cardiometabolic conditions. Overall, no differences were observed between the percentage of participants in the GS and control arms, who reported changes to health behaviors such as diet and exercise at 6 months post disclosure (48% vs. 36%, respectively, p =

SUBMITTER: Christensen KD 

PROVIDER: S-EPMC8384838 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature