Evaluation of a mechanical lung model to test small animal whole body plethysmography.

ABSTRACT: Whole-body plethysmography (WBP) is an established method to determine physiological parameters and pathophysiological alteration of breathing in animals and animal models of a variety of diseases. Although frequently used, there is ongoing debate about what exactly is measured by whole-body-plethysmography and how reliable the data derived from this method are. Here, we designed an artificial lung model that enables a thorough evaluation of different predictions about and around whole-body plethysmography. Using our lung model, we confirmed that during WBP two components contribute to the pressure changes detected in the chamber: (1) the increase in the pressure due to heating and moistening of the air during inspiration, termed conditioning; (2) changes in the chamber pressure that depen

SUBMITTER: Hulsmann S 

PROVIDER: S-EPMC8384843 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature