Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response.

ABSTRACT: Microphysiological in vitro systems are platforms for preclinical evaluation of drug effects and significant advances have been made in recent years. However, existing microfluidic devices are not yet able to deliver compounds to cell models in a way that reproduces the real physiological drug exposure. Here, we introduce a novel tumour-on-chip microfluidic system that mimics the pharmacokinetic profile of compounds on 3D tumour spheroids to evaluate their response to the treatments. We used this platform to test the response of SW620 colorectal cancer spheroids to irinotecan (SN38) alone and in combination with the ATM inhibitor AZD0156, using concentrations mimicking mouse plasma exposure profiles of both agents. We explored spheroid volume and viability as a measure of cancer cells resp

SUBMITTER: Petreus T 

PROVIDER: S-EPMC8385015 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature