Neural substrates of propranolol-induced impairments in the reconsolidation of nicotine-associated memories in smokers.

ABSTRACT: The majority of smokers relapse even after successfully quitting because of the craving to smoking after unexpectedly re-exposed to smoking-related cues. This conditioned craving is mediated by reward memories that are frequently experienced and stubbornly resistant to treatment. Reconsolidation theory posits that well-consolidated memories are destabilized after retrieval, and this process renders memories labile and vulnerable to amnestic intervention. This study tests the retrieval reconsolidation procedure to decrease nicotine craving among people who smoke. In this study, 52 male smokers received a single dose of propranolol (n = 27) or placebo (n = 25) before the reactivation of nicotine-associated memories to impair the reconsolidation process. Craving for smoking and neural activit

SUBMITTER: Lin X 

PROVIDER: S-EPMC8385067 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature