Cubosomal lipid formulation of nitroalkene fatty acids: Preparation, stability and biological effects.

ABSTRACT: Lipid nitroalkenes - nitro-fatty acids (NO₂-FAs) are formed in vivo via the interaction of reactive nitrogen species with unsaturated fatty acids. The resulting electrophilic NO₂-FAs play an important role in redox homeostasis and cellular stress response. This study investigated the physicochemical properties and reactivity of two NO₂-FAs: 9/10-nitrooleic acid (1) and its newly prepared 1-monoacyl ester, (E)-2,3-hydroxypropyl 9/10-nitrooctadec-9-enoate (2), both synthesized by a direct radical nitration approach. Compounds 1 and 2 were investigated in an aqueous medium and after incorporation into lipid nanoparticles prepared from 1-monoolein, cubosomes 1@CUB and 2@CUB. Using an electrochemical analysis and LC-MS, free 1 and 2 were found to be unstable und

SUBMITTER: Zatloukalova M 

PROVIDER: S-EPMC8385161 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature