Species interactions drive the spread of ampicillin resistance in human-associated gut microbiota.

ABSTRACT:

Background and objectives

Slowing the spread of antimicrobial resistance is urgent if we are to continue treating infectious diseases successfully. There is increasing evidence microbial interactions between and within species are significant drivers of resistance. On one hand, cross-protection by resistant genotypes can shelter susceptible microbes from the adverse effects of antibiotics, reducing the advantage of resistance. On the other hand, antibiotic-mediated killing of susceptible genotypes can alleviate competition and allow resistant strains to thrive (competitive release). Here, by observing interactions both within and between species in microbial communities sampled from humans, we investigate the potential role for cross-protection and competitive release in driving th

SUBMITTER: O'Brien S 

PROVIDER: S-EPMC8385247 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature