Adaptation to DNA damage as a bet-hedging mechanism in a fluctuating environment.

ABSTRACT: In response to DNA damage, efficient repair is essential for cell survival and genome integrity. In eukaryotes, the DNA damage checkpoint is a signalling pathway that coordinates this response and arrests the cell cycle to provide time for repair. However, when repair fails or when the damage is not repairable, cells can eventually bypass the DNA damage checkpoint and undergo cell division despite persistent damage, a process called adaptation to DNA damage. Interestingly, adaptation occurs with a delayed timing compared with repair and shows a large variation in time, two properties that may provide a survival advantage at the population level without interfering with repair. Here, we explore this idea by mathematically modelling cell survival in response to DNA damage and focusing on ada

SUBMITTER: Roux P 

PROVIDER: S-EPMC8385375 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature