Recurrence risk of occult micrometastases and isolated tumor cells in early stage endometrial cancer: A case control study.

ABSTRACT:

Objectives

To determine whether previously undetected occult micrometastasis (MM) or isolated tumor cells (ITC) is associated with increased recurrence odds in stage I-II endometrioid adenocarcinoma.

Methods

Women with recurrent stage I/II EC who had complete pelvic and para-aortic were identified as the outcome of interest. A case-control study was designed with the exposure defined as occult MM/ITC not seen on original nodal pathology. Controls were found by frequency-matching in a 1:2 case control ratio. Original nodal slides were re-reviewed, stained and tested with immunohistochemical to detect occult MM/ITC and the odds of associated recurrence was calculated.

Results

Of 153 included, 50 with and 103 without recurrence, there was no difference in age (p = 0.46),

SUBMITTER: Castellano T 

PROVIDER: S-EPMC8385390 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature