Lung Function Impairment and the Risk of Incident Dementia: The Rotterdam Study.

ABSTRACT:

Background

The etiology of dementia may partly be underpinned by impaired lung function via systemic inflammation and hypoxia.

Objective

To prospectively examine the association between chronic obstructive pulmonary disease (COPD) and subclinical impairments in lung function and the risk of dementia.

Methods

In the Rotterdam Study, we assessed the risk of incident dementia in participants with Preserved Ratio Impaired Spirometry (PRISm; FEV1/FVC≥0.7, FEV1 < 80% predicted) and in participants with COPD (FEV1/FVC < 0.7) compared to those with normal spirometry (controls; FEV1/FVC≥0.7, FEV1≥80% predicted). Hazard ratios (HRs) with 95% confidence intervals (CI) for dementia were adjusted for age, sex, education attainment, smoking status, systolic blood pressure, body mas

SUBMITTER: Xiao T 

PROVIDER: S-EPMC8385522 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature