Clec4e-Receptor Signaling in Myocardial Repair After Ischemia-Reperfusion Injury.

ABSTRACT: The bacterial C-type lectin domain family 4 member E (CLEC4E) has an important role in sterile inflammation, but its role in myocardial repair is unknown. Using complementary approaches in porcine, murine, and human samples, we show that CLEC4E expression levels in the myocardium and in blood correlate with the extent of myocardial injury and left ventricular (LV) functional impairment. CLEC4E expression is markedly increased in the vasculature, cardiac myocytes, and infiltrating leukocytes in the ischemic heart. Loss of Clec4e signaling is associated with reduced acute cardiac injury, neutrophil infiltration, and infarct size. Reduced myocardial injury in Clec4e ^-/- translates into significantly improved LV structural and functional remodeling at 4 w

SUBMITTER: Veltman D 

PROVIDER: S-EPMC8385568 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature