Pima Indian Contributions to Our Understanding of Diabetic Kidney Disease.

ABSTRACT: Prospective studies in informative populations are crucial to increasing our knowledge of disease. In this perspective, we describe a half century of studies in an American Indian population that transformed our understanding of kidney disease in type 2 diabetes, now recognized as the leading cause of kidney failure worldwide. Serial examinations conducted for many years that included the collection of data and samples across multiple domains captured an unprecedented volume of clinical, physiologic, morphometric, genomic, and transcriptomic data. This work permitted us to extensively characterize the course and determinants of diabetic kidney disease, its pathophysiologic underpinnings, and important secular trends of urgent concern to populations worldwide, including the emergence of you

SUBMITTER: Nelson RG 

PROVIDER: S-EPMC8385607 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature