Structural and developmental principles of neuropil assembly in C. elegans.

ABSTRACT: Neuropil is a fundamental form of tissue organization within the brain¹, in which densely packed neurons synaptically interconnect into precise circuit architecture^2,3. However, the structural and developmental principles that govern this nanoscale precision remain largely unknown^4,5. Here we use an iterative data coarse-graining algorithm termed 'diffusion condensation'⁶ to identify nested circuit structures within the Caenorhabditis elegans neuropil, which is known as the nerve ring. We show that the nerve ring neuropil is largely organized into four strata that are composed of related behavioural circuits. The stratified architecture of the neuropil is a geometrical representation of the functional segregation of sensory information and motor

SUBMITTER: Moyle MW 

PROVIDER: S-EPMC8385650 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature