Exogenous Introduction of Initiator and Executioner Caspases Results in Different Apoptotic Outcomes.

ABSTRACT: The balance of pro-apoptotic and pro-survival proteins defines a cell's fate. These processes are controlled through an interdependent and finely tuned protein network that enables survival or leads to apoptotic cell death. The caspase family of proteases is central to this apoptotic network, with initiator and executioner caspases, and their interaction partners, regulating and executing apoptosis. In this work, we interrogate and modulate this network by exogenously introducing specific initiator or executioner caspase proteins. Each caspase is exogenously introduced using redox-responsive polymeric nanogels. Although caspase-3 might be expected to be the most effective due to the centrality of its role in apoptosis and its heightened catalytic efficiency relative to other family members

SUBMITTER: Anson F 

PROVIDER: S-EPMC8385707 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature