Ylide-Substituted Phosphines with a Cyclic Ylide-Backbone: Angle Dependence of the Donor Strength.

ABSTRACT: Ylide-substituted phosphines (YPhos) have been shown to be highly electron-rich and efficient ligands in a variety of palladium catalyzed transformations. Here, the synthesis and characterization of novel YPhos ligands containing a cyclic backbone architecture are reported. The ligands are easily synthesized from a cyclic phosphonium salt and the chlorophosphines Cy₂PCl (L1) and Cy(Flu^Me)PCl (L2, with Flu^Me = 9-methylfluorenyl) and were characterized in both solution and solid states. The smaller PCy₂-substituted ligand, L1, readily formed the biscoordinate L1 ₂ Pd species when treated with Pd₂(dba)₃ and showed no activity in palladium-catalyzed amination reactions even wh

SUBMITTER: Loffler J 

PROVIDER: S-EPMC8385760 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature