Neuroprotection in early stages of Alzheimer's disease is promoted by transthyretin angiogenic properties.

ABSTRACT:

Background

While still controversial, it has been demonstrated that vascular defects can precede the onset of other AD hallmarks features, making it an important therapeutic target. Given that the protein transthyretin (TTR) has been established as neuroprotective in AD, here we investigated the influence of TTR in the vasculature.

Methods

We evaluated the thickness of the basement membrane and the length of brain microvessels, by immunohistochemistry, in AβPPswe/PS1A246E (AD) transgenic mice and non-transgenic mice (NT) bearing one (TTR+/-) or two (TTR+/+) copies of the TTR gene. The angiogenic potential of TTR was evaluated in vitro using the tube formation assay, and in vivo using the chick chorioallantoic membrane (CAM) assay.

Results

AD transgenic mice with TTR g

SUBMITTER: Giao T 

PROVIDER: S-EPMC8385857 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature