Association of VEGF haplotypes with breast cancer risk in North-West Indians.

ABSTRACT:

Background

Angiogenesis is a complex and coordinated process regulated by different growth factors and is one of the hallmark features of cancer. VEGF is one of the most important endothelial cell mitogen and has a critical role in normal physiological and tumor angiogenesis. The objective of this study was to investigate the potential association of haplotypes of six VEGF polymorphisms with breast cancer risk in North-West Indians.

Methods

Samples of 250 breast cancer patients and 250 age and sex matched controls were genotyped for VEGF -2578C/A, -2549I/D, -460T/C, +405C/G, -7C/T and +936C/T polymorphisms. Haplotypes were generated to determine the better contribution of VEGF polymorphisms to breast cancer risk.

Results

Haplotypes CDTCCC (OR = 0.56, 95%CI, 0.38-0.81;

SUBMITTER: Sambyal V 

PROVIDER: S-EPMC8386001 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature