Integrative enrichment analysis of gene expression based on an artificial neuron.

ABSTRACT:

Background

Huntington's disease is a kind of chronic progressive neurodegenerative disease with complex pathogenic mechanisms. To data, the pathogenesis of Huntington's disease is still not fully understood, and there has been no effective treatment. The rapid development of high-throughput sequencing technologies makes it possible to explore the molecular mechanisms at the transcriptome level. Our previous studies on Huntington's disease have shown that it is difficult to distinguish disease-associated genes from non-disease genes. Meanwhile, recent progress in bio-medicine shows that the molecular origin of chronic complex diseases may not exist in the diseased tissue, and differentially expressed genes between different tissues may be helpful to reveal the molecular origin of ch

SUBMITTER: Jiang X 

PROVIDER: S-EPMC8386081 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature