Different resting-state network disruptions in newly diagnosed drug-naive Parkinson's disease patients with mild cognitive impairment.

ABSTRACT:

Background

Cognitive impairment is a common non-motor symptom in patients with Parkinson's disease (PD). Mild cognitive impairment (MCI) is also prevalent in nondemented PD patients, even in newly diagnosed PD patients. The possible impacts of MCI on brain function activities for PD patients need more investigation, and the potential of emerging technologies for detecting underlying pathophysiology of cognitive signs in PD can be further improved.

Method

Forty-seven newly diagnosed drug-naïve PD patients (28 PD-MCI patients and 19 PD patients with cognitively unimpaired (PD-CU)) and 28 healthy controls (HCs) underwent resting-state functional MRI. The connectivity patterns of specific networks were investigated through the independent component analysis among PD-MCI, PD-CU a

SUBMITTER: Hou Y 

PROVIDER: S-EPMC8386092 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature